预约演示 免费注册 更新于：2025-05-07 DDX11L1 更新于：2025-05-07 基本信息 别名 DDX11L1、 DEAD/H-box helicase 11 like 1 (pseudogene) 简介 - 关联 100 项与 DDX11L1 相关的临床结果 登录后查看更多信息 100 项与 DDX11L1 相关的转化医学 登录后查看更多信息 0 项与 DDX11L1 相关的专利（医药） 登录后查看更多信息 2 项与 DDX11L1 相关的文献（医药） 2022-09-15 · Nature African-specific molecular taxonomy of prostate cancer Article 作者: Willet, Cali ; Haynes, Anne-Maree ; Brum, Ilma Simoni ; Mutambirwa, Shingai B A ; Pasqualim, Gabriela ; Jiang, Jue ; Gong, Tingting ; Hayes, Vanessa M ; Stricker, Phillip D ; Patrick, Sean M ; Wedge, David C ; Chan, Eva K F ; Campbell, Raymond ; Sadsad, Rosemarie ; Louw, Melanie ; Bornman, M S Riana ; Horvath, Lisa G ; Chew, Tracy ; Lyons, Ruth J ; Jaratlerdsiri, Weerachai ; Kench, James G Abstract Prostate cancer is characterized by considerable geo-ethnic disparity. African ancestry is a significant risk factor, with mortality rates across sub-Saharan Africa of 2.7-fold higher than global averages 1 . The contributing genetic and non-genetic factors, and associated mutational processes, are unknown 2,3 . Here, through whole-genome sequencing of treatment-naive prostate cancer samples from 183 ancestrally (African versus European) and globally distinct patients, we generate a large cancer genomics resource for sub-Saharan Africa, identifying around 2 million somatic variants. Significant African-ancestry-specific findings include an elevated tumour mutational burden, increased percentage of genome alteration, a greater number of predicted damaging mutations and a higher total of mutational signatures, and the driver genes NCOA2 , STK19 , DDX11L1 , PCAT1 and SETBP1 . Examining all somatic mutational types, we describe a molecular taxonomy for prostate cancer differentiated by ancestry and defined as global mutational subtypes (GMS). By further including Chinese Asian data, we confirm that GMS-B (copy-number gain) and GMS-D (mutationally noisy) are specific to African populations, GMS-A (mutationally quiet) is universal (all ethnicities) and the African–European-restricted subtype GMS-C (copy-number losses) predicts poor clinical outcomes. In addition to the clinical benefit of including individuals of African ancestry, our GMS subtypes reveal different evolutionary trajectories and mutational processes suggesting that both common genetic and environmental factors contribute to the disparity between ethnicities. Analogous to gene–environment interaction—defined here as a different effect of an environmental surrounding in people with different ancestries or vice versa—we anticipate that GMS subtypes act as a proxy for intrinsic and extrinsic mutational processes in cancers, promoting global inclusion in landmark studies. Scientific Reports The impact of telomere length on prostate cancer aggressiveness, genomic instability and health disparities Article 作者: Jaratlerdsiri, Weerachai ; Mutambirwa, Shingai B A ; Simoni Brum, Ilma ; Bornman, M S Riana ; Hayes, Vanessa M ; Stricker, Phillip D ; Huang, Ruotian Abstract The telomere repetitive TTAGGG motif at the ends of chromosomes, serves to preserve genomic integrity and chromosomal stability. In turn, genomic instability is a hallmark of cancer—implicating telomere disturbance. Prostate cancer (PCa) shows significant ancestral disparities, with men of African ancestry at the greatest risk for aggressive disease and associated genomic instability. Yet, no study has explored the role of telomere length (TL) with respect to ancestrally driven PCa health disparities. Patient- and technically-matched tumour-blood whole genome sequencing data for 179 ancestrally defined treatment naïve PCa patients (117 African, 62 European), we assessed for TL (blood and tumour) associations. We found shortened tumour TL to be associated with aggressive PCa presentation and elevated genomic instabilities, including percentage of genome alteration and copy number gains, in men of African ancestry. For European patients, tumour TL showed significant associations with PCa driver genes PTEN , TP53 , MSH2 , SETBP1 and DDX11L1 , while shorter blood TL (< 3200 base pairs) and tumour TL (< 2861 base pairs) were correlated with higher risk for biochemical recurrence. Concurring with previous studies linking TL to PCa diagnosis and/or prognosis, for the first time we correlated TL differences with patient ancestry with important implications for future treatments targeting telomere dysfunction. 分析 对领域进行一次全面的分析。 登录 或 查看完整样例数据 提出任何生物医药研究问题 让每一步生物医药决策都精准制胜 基于十亿级生物数据与全球情报的精准 AI，赋能早期药物发现 立即开始免费试用! 智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。 开始免费试用 立即接入生物医药数据包 智慧芽新药库数据也通过智慧芽开放平台，以MCP或API服务形式对外开放。立即使用我们的MCP服务定制您的LLM智能体。 准备好接入了吗？ 立即获取API秘钥→ 生物序列数据库 生物药研发创新 免费使用 化学结构数据库 小分子化药研发创新 免费使用